Reprogramming antitumor immunity against chemoresistant ovarian cancer by a CXCR4 antagonist-armed viral oncotherapy

Ovarian cancer remains the most lethal gynecologic malignancy owing to late detection, intrinsic and acquired chemoresistance, and remarkable heterogeneity. Here, we explored approaches to inhibit metastatic growth of murine and human ovarian tumor variants resistant to paclitaxel and carboplatin by...

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Bibliographic Details
Main Authors: Marcin P Komorowski, AJ Robert McGray, Agnieszka Kolakowska, Kevin Eng, Margaret Gil, Mateusz Opyrchal, Bogumila Litwinska, Michael J Nemeth, Kunle O Odunsi, Danuta Kozbor
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770516300675