Pentosan polysulfate binds to STRO-1+ mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programing stem cells for therapeutic application requiring their chondrogenesis

Pentosan polysulfate binds to STRO-1+ mesenchymal progenitor cells, is internalized, and modifies gene expression: a novel approach of pre-programing stem cells for therapeutic application requiring their chondrogenesis

Abstract Background The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS in mediating these effects remains unresolved. In the present report we...

Full description

Bibliographic Details
Main Authors: Jiehua Wu, Susan Shimmon, Sharon Paton, Christopher Daly, Tony Goldschlager, Stan Gronthos, Andrew C. W. Zannettino, Peter Ghosh
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal progenitor cells
Pentosan polysulfate
Heparin
Chondrogenesis
Proliferation
Gene expression
Online Access:http://link.springer.com/article/10.1186/s13287-017-0723-y

Internet

http://link.springer.com/article/10.1186/s13287-017-0723-y

Similar Items