Active Mechanistic Target of Rapamycin plays an ancillary rather than essential role in Zebrafish CNS axon regeneration

Active Mechanistic Target of Rapamycin plays an ancillary rather than essential role in Zebrafish CNS axon regeneration

The developmental decrease of the intrinsic regenerative ability of the mammalian central nervous system (CNS) is associated with reduced activity of mechanistic target of rapamycin (mTOR) in mature neurons such as retinal ganglion cells (RGCs). While mTOR activity is further decreased upon axonal i...

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Bibliographic Details
Main Authors: Heike eDiekmann, Pascal eKalbhen, Dietmar eFischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Zebrafish
mTOR
rapamycin
pS6
optic nerve regeneration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00251/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00251/full

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