Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation

Inhibition of CXCR4 and CXCR7 Is Protective in Acute Peritoneal Inflammation

Our previous studies revealed a pivotal role of the chemokine stromal cell-derived factor (SDF)-1 and its receptors CXCR4 and CXCR7 on migratory behavior of polymorphonuclear granulocytes (PMNs) in pulmonary inflammation. Thereby, the SDF-1-CXCR4/CXCR7-axis was linked with adenosine signaling. Howev...

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Bibliographic Details
Main Authors: Kristian-Christos Ngamsri, Christoph Jans, Rizki A. Putri, Katharina Schindler, Jutta Gamper-Tsigaras, Claudia Eggstein, David Köhler, Franziska M. Konrad
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
PMN
neutrophil
SDF-1
stromal cell-derived factor
tight junction proteins
adenosine receptor A2B
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00407/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00407/full

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