MMP-14 overexpression correlates with the neurodegenerative process in familial amyloidotic polyneuropathy

Levels of matrix metalloproteases (MMPs) can be differentially regulated in response to injury or neurological diseases. For instance, it is known that selective and short-term inhibition of MMP-14, a membrane-type 1 MMP, accelerates axon regeneration. Because axon growth and regeneration is impaire...

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Bibliographic Details
Main Authors: Diana Martins, João Moreira, Nádia Pereira Gonçalves, Maria João Saraiva
Format: Article
Language:English
Published: The Company of Biologists 2017-10-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/10/10/1253