Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways

Abstract Background Mesothelioma is resistant to conventional treatments and is often defective in p53 pathways. We then examined anti-tumor effects of metformin, an agent for type 2 diabetes, and combinatory effects of metformin and nutlin-3a, an inhibitor for ubiquitin-mediated p53 degradation, on...

Full description

Bibliographic Details
Main Authors: Kengo Shimazu, Yuji Tada, Takao Morinaga, Masato Shingyoji, Ikuo Sekine, Hideaki Shimada, Kenzo Hiroshima, Takao Namiki, Koichiro Tatsumi, Masatoshi Tagawa
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Mesothelioma
Metformin
Nutlin-3a
p53
Mammalian target of rapamycin
Online Access:http://link.springer.com/article/10.1186/s12885-017-3300-y

Internet

http://link.springer.com/article/10.1186/s12885-017-3300-y

Similar Items