Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

Ryanodine receptor type I-related myopathies (RYR1-RMs) are a common group of childhood muscle diseases associated with severe disabilities and early mortality for which there are no available treatments. The goal of this study is to identify new therapeutic targets for RYR1-RMs. To accomplish this,...

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Bibliographic Details
Main Authors: Jonathan R Volpatti, Yukari Endo, Jessica Knox, Linda Groom, Stephanie Brennan, Ramil Noche, William J Zuercher, Peter Roy, Robert T Dirksen, James J Dowling
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
RYR1
myopathy
drug screen
excitation contraction coupling
animal models
Online Access:https://elifesciences.org/articles/52946

Internet

https://elifesciences.org/articles/52946

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