G-CSF and G-CSFR Induce a Pro-Tumorigenic Macrophage Phenotype to Promote Colon and Pancreas Tumor Growth

G-CSF and G-CSFR Induce a Pro-Tumorigenic Macrophage Phenotype to Promote Colon and Pancreas Tumor Growth

Tumor-associated macrophages (TAMs) in the gastrointestinal tumor microenvironment (TME) are known to polarize into populations exhibiting pro- or anti-tumoral activity in response to stimuli such as growth factors and cytokines. Our previous work has recognized granulocyte colony-stimulating factor...

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Bibliographic Details
Main Authors: Ioannis Karagiannidis, Eliane de Santana Van Vilet, Erika Said Abu Egal, Brandon Phinney, Damian Jacenik, Eric R. Prossnitz, Ellen J. Beswick
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
G-CSF
G-CSFR
TAMs
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/12/10/2868

Internet

https://www.mdpi.com/2072-6694/12/10/2868

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