Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification

Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in blood have not been reported, but would facilitate diagnostic test development. To identify minimal transcript sign...

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Bibliographic Details
Main Authors: Harriet D. Gliddon, Myrsini Kaforou, Mary Alikian, Dominic Habgood-Coote, Chenxi Zhou, Tolu Oni, Suzanne T. Anderson, Andrew J. Brent, Amelia C. Crampin, Brian Eley, Robert Heyderman, Florian Kern, Paul R. Langford, Tom H. M. Ottenhoff, Martin L. Hibberd, Neil French, Victoria J. Wright, Hazel M. Dockrell, Lachlan J. Coin, Robert J. Wilkinson, Michael Levin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
transcriptomics
dPCR
gene expression
signatures
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637164/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.637164/full

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