Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation Anti–PD-1 Treatment Efficacy in Urothelial Carcinoma

Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation Anti–PD-1 Treatment Efficacy in Urothelial Carcinoma

The therapeutic benefit of immune checkpoint inhibitor monotherapy is limited to a subset of patients in urothelial carcinoma (UC). Previous studies showed the immunogenicity of cisplatin and irradiation. Here, we investigated whether chemoradiotherapy (CRT), a combination of cisplatin and irradiati...

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Bibliographic Details
Main Authors: Hiroshi Fukushima, Soichiro Yoshida, Toshiki Kijima, Yuki Nakamura, Shohei Fukuda, Sho Uehara, Yosuke Yasuda, Hajime Tanaka, Minato Yokoyama, Yoh Matsuoka, Yasuhisa Fujii
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
chemoradiotherapy
cisplatin
immunotherapy
carcinoma
transitional cell
immunogenic cell death
Online Access:https://www.mdpi.com/1422-0067/22/2/535

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https://www.mdpi.com/1422-0067/22/2/535

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