SMEAF attenuates the production of pro-inflammatory mediators through the inactivation of Akt-dependent NF-κB, p38 and ERK1/2 pathways in LPS-stimulated BV-2 microglial cells

SMEAF attenuates the production of pro-inflammatory mediators through the inactivation of Akt-dependent NF-κB, p38 and ERK1/2 pathways in LPS-stimulated BV-2 microglial cells

The ethyl acetate fraction from the seeds of Swietenia macrophylla (SMEAF) was studied for anti-inflammatory properties using lipopolysaccharide (LPS)-induced BV-2 microglia. SMEAF significantly attenuated the LPS-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclo...

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Bibliographic Details
Main Authors: Hadi Supriady, Muhamad Noor Alfarizal Kamarudin, Chim Kei Chan, Bey Hing Goh, Habsah Abdul Kadir
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Journal of Functional Foods
Subjects:
Swietenia macrophylla
Anti-inflammatory
BV-2 microglial cells
MAPKs
Akt
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615002819

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http://www.sciencedirect.com/science/article/pii/S1756464615002819

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