Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging

<p>Abstract</p> <p>Background</p> <p>The TAR hairpin is present at both the 5′ and 3′ end of the HIV-1 RNA genome. The 5′ element binds the viral Tat protein and is essential for Tat-mediated activation of transcription. We recently observed that complete TAR deletion i...

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Bibliographic Details
Main Authors: Das Atze T, Vrolijk Martine M, Harwig Alex, Berkhout Ben
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Retrovirology
Subjects:
HIV-1
TAR
Dimerization
Packaging
RNA structure
Online Access:http://www.retrovirology.com/content/9/1/59

Internet

http://www.retrovirology.com/content/9/1/59

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