Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearance and increased susceptibility to bleomycin-induc...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-07768-9 |