Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.

Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.

Resting memory CD4+ T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat have been shown to induce HIV expression in these resting cells. Recently, it...

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Bibliographic Details
Main Authors: Richard Brad Jones, Rachel O'Connor, Stefanie Mueller, Maria Foley, Gregory L Szeto, Dan Karel, Mathias Lichterfeld, Colin Kovacs, Mario A Ostrowski, Alicja Trocha, Darrell J Irvine, Bruce D Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4133386?pdf=render

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http://europepmc.org/articles/PMC4133386?pdf=render

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