TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.

Bibliographic Details
Main Authors: Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, László Tora
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20239-4

Internet

https://doi.org/10.1038/s41467-020-20239-4

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