TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.

Bibliographic Details
Main Authors: Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, László Tora
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20239-4
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spelling doaj-17a2545846504f2fb6572d460793c1a32021-01-31T13:18:28ZengNature Publishing GroupNature Communications2041-17232020-12-0111111310.1038/s41467-020-20239-4TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usageChangwei Yu0Nevena Cvetesic1Vincent Hisler2Kapil Gupta3Tao Ye4Emese Gazdag5Luc Negroni6Petra Hajkova7Imre Berger8Boris Lenhard9Ferenc Müller10Stéphane D. Vincent11László Tora12Institut de Génétique et de Biologie Moléculaire et CellulaireImperial College London, South Kensington CampusInstitut de Génétique et de Biologie Moléculaire et CellulaireMax Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock’s CloseInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireImperial College London, South Kensington CampusMax Planck Bristol Centre for Minimal Biology, University of Bristol, Cantock’s CloseImperial College London, South Kensington CampusInstitute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of BirminghamInstitut de Génétique et de Biologie Moléculaire et CellulaireInstitut de Génétique et de Biologie Moléculaire et CellulaireThe vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.https://doi.org/10.1038/s41467-020-20239-4
collection DOAJ
language English
format Article
sources DOAJ
author Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
spellingShingle Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
Nature Communications
author_facet Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
author_sort Changwei Yu
title TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_short TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_full TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_fullStr TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_full_unstemmed TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_sort tbpl2/tfiia complex establishes the maternal transcriptome through oocyte-specific promoter usage
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-12-01
description The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.
url https://doi.org/10.1038/s41467-020-20239-4
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