ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P<sub>1</sub> Agonist and Functional Antagonist Potency In Vitro and In Vivo

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P<sub>1</sub> Agonist and Functional Antagonist Potency In Vitro and In Vivo

Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P<sub>1</sub> internalization upon S1P binding and recycling to the cell su...

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Bibliographic Details
Main Authors: Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea Huwiler
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
sphingosine 1-phosphate
S1P<sub>1</sub> receptor
functional antagonism
lymphopenia
ST-2191
anellated bismorpholino
Online Access:https://www.mdpi.com/1420-3049/26/17/5134

Internet

https://www.mdpi.com/1420-3049/26/17/5134

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