Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice

Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice

A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the “metabolic syndrome,” is known to increase the risk of developing cardiovascular disease and diabetes. Stearoyl-coenzyme A desaturase (SCD) activity has been i...

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Bibliographic Details
Main Authors: Marcia L.E. MacDonald, Roshni R. Singaraja, Nagat Bissada, Piers Ruddle, Russell Watts, Joanna M. Karasinska, William T. Gibson, Catherine Fievet, Jean E. Vance, Bart Staels, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Lipid Research
Subjects:
monounsaturated fatty acids
very low density lipoprotein
high density lipoprotein
apolipoprotein B
mouse model
liver
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428962

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http://www.sciencedirect.com/science/article/pii/S0022227520428962

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