Feedback Regulation of <i>O</i>-GlcNAc Transferase through Translation Control to Maintain Intracellular <i>O</i>-GlcNAc Homeostasis

Feedback Regulation of <i>O</i>-GlcNAc Transferase through Translation Control to Maintain Intracellular <i>O</i>-GlcNAc Homeostasis

Protein <i>O</i>-GlcNAcylation is a dynamic post-translational modification involving the attachment of <i>N</i>-acetylglucosamine (GlcNAc) to the hydroxyl groups of Ser/Thr residues on numerous nucleocytoplasmic proteins. Two enzymes are responsible for <i>O</i>-...

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Bibliographic Details
Main Authors: Chia-Hung Lin, Chen-Chung Liao, Mei-Yu Chen, Teh-Ying Chou
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
epigenetics
eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
histone deacetylase (HDAC)
<i>O</i>-GlcNAcase (OGA)
<i>O</i>-GlcNAcylation
<i>O</i>-linked <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAc)
Online Access:https://www.mdpi.com/1422-0067/22/7/3463

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https://www.mdpi.com/1422-0067/22/7/3463

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