Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias

<p>Abstract</p> <p>T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk type of blood-cell cancer. We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells. Virotherapy is based on the exclusive replication of a virus in leukemic cells, l...

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Bibliographic Details
Main Authors: Berkhout Ben, van den Berg Henk, Jan Barbara, Jeeninga Rienk E
Format: Article
Language:English
Published: BMC 2006-09-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/3/1/64