Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Summary: Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and differentiated cardiomyocytes. Using two conditional murine k...

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Bibliographic Details
Main Authors: Abir Yamak, Dongjian Hu, Nikhil Mittal, Jan W. Buikema, Sheraz Ditta, Pierre G. Lutz, Christel Moog-Lutz, Patrick T. Ellinor, Ibrahim J. Domian
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220301437

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http://www.sciencedirect.com/science/article/pii/S2589004220301437

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