Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

Fab consist of a heavy and light chain and can be subdivided into a variable (VH and VL) and a constant region (CH1 and CL). The variable region contains the complementarity-determining region (CDR), which is formed by six hypervariable loops, shaping the antigen binding site, the paratope. Apart fr...

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Bibliographic Details
Main Authors: Monica L. Fernández-Quintero, Katharina B. Kroell, Martin C. Heiss, Johannes R. Loeffler, Patrick K. Quoika, Franz Waibl, Alexander Bujotzek, Ekkehard Moessner, Guy Georges, Klaus R. Liedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
VH–VL interface dynamics
CH1–CL dynamics
elbow angle
antibody structure design
antibody structure prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.609088/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2020.609088/full

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