Effects of long-term alendronate treatment on bone mineralisation, resorption parameters and biomechanics of single human vertebral trabeculae

Effects of long-term alendronate treatment on bone mineralisation, resorption parameters and biomechanics of single human vertebral trabeculae

Due to their well-established fracture risk reduction, bisphosphonates are the most frequently used therapeutic agent to treat osteoporosis. Bisphosphonates reduce fracture risk by suppressing bone resorption, but the lower bone turnover could have a negative impact on bone quality at the tissue lev...

Full description

Bibliographic Details
Main Authors: M Krause, M Soltau, EA Zimmermann, M Hahn, J Kornet, A Hapfelmeier, S Breer, M Morlock, B Wulff, K Püschel, C-C Glueer, M Amling, B Busse
Format: Article
Language:English
Published: AO Research Institute Davos 2014-09-01
Series:European Cells & Materials
Subjects:
Osteoporosis
alendronate
histomorphometry
microcomputed-tomography
mineralisation
microdamage
Online Access:http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a12.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol028/pdf/v028a12.pdf

Similar Items