Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

Summary: NTRK1 gene fusions are actionable drivers of numerous human malignancies. Here, we show that expression of the TPR-NTRK1 fusion kinase in immortalized mouse pancreatic ductal epithelial (IMPE) (pancreas) or mouse lung epithelial (MLE-12) cells is sufficient to promote rapidly growing tumors...

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Bibliographic Details
Main Authors: Aria Vaishnavi, Michael T. Scherzer, Conan G. Kinsey, Gennie L. Parkman, Amanda Truong, Phaedra Ghazi, Sophia Schuman, Benjamin Battistone, Ignacio Garrido-Laguna, Martin McMahon
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
NTRK gene fusion
kinase oncoproteins
pathway-targeted therapies
lung cancer
colorectal cancer
pancreatic cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309797

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http://www.sciencedirect.com/science/article/pii/S2211124720309797

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