Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.

Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells.

Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell populations and are highly resistant to standard chemotherapy. Here we demonstrate that metformin selectively ablated pancrea...

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Bibliographic Details
Main Authors: Enza Lonardo, Michele Cioffi, Patricia Sancho, Yolanda Sanchez-Ripoll, Sara Maria Trabulo, Jorge Dorado, Anamaria Balic, Manuel Hidalgo, Christopher Heeschen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3799760?pdf=render

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http://europepmc.org/articles/PMC3799760?pdf=render

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