Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.

Bibliographic Details
Main Authors: Walter F. Mangel, William J. McGrath, Kan Xiong, Vito Graziano, Paul C. Blainey
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10202