Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA

Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.

Bibliographic Details
Main Authors: Walter F. Mangel, William J. McGrath, Kan Xiong, Vito Graziano, Paul C. Blainey
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10202
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spelling doaj-17ca686a1607463e8cf9d6dac2de694a2021-05-11T10:44:15ZengNature Publishing GroupNature Communications2041-17232016-02-017111110.1038/ncomms10202Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNAWalter F. Mangel0William J. McGrath1Kan Xiong2Vito Graziano3Paul C. Blainey4Department of Biology, Brookhaven National LaboratoryDepartment of Biology, Brookhaven National LaboratoryDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Biology, Brookhaven National LaboratoryDepartment of Biological Engineering, Massachusetts Institute of TechnologyExtremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.https://doi.org/10.1038/ncomms10202
collection DOAJ
language English
format Article
sources DOAJ
author Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
spellingShingle Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
Nature Communications
author_facet Walter F. Mangel
William J. McGrath
Kan Xiong
Vito Graziano
Paul C. Blainey
author_sort Walter F. Mangel
title Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_short Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_full Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_fullStr Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_full_unstemmed Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA
title_sort molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along dna
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-02-01
description Extremely compact environments can inhibit protein interactions by preventing 3-dimensional diffusion. Here the authors show that an 11-amino acid long peptide can function as a ‘molecular sled’, able to transport cargo linearly along DNA to enable interactions.
url https://doi.org/10.1038/ncomms10202
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AT kanxiong molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT vitograziano molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
AT paulcblainey molecularsledisanelevenaminoacidvehiclefacilitatingbiochemicalinteractionsviaslidingcomponentsalongdna
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