Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia

Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia

We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identif...

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Bibliographic Details
Main Authors: Meenakshi Sundaram, Shumei Zhong, Maroun Bou Khalil, Hu Zhou, Zhenghui G. Jiang, Yang Zhao, Jahangir Iqbal, M. Mahmood Hussain, Daniel Figeys, Yuwei Wang, Zemin Yao
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of Lipid Research
Subjects:
triacylglycerol
VLDL assembly
apolipoprotein C-III
lumenal lipid droplets
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410272

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http://www.sciencedirect.com/science/article/pii/S0022227520410272

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