Gender-Related Impact of Sclerostin Antibody on Bone in the Osteogenesis Imperfecta Mouse

Gender-Related Impact of Sclerostin Antibody on Bone in the Osteogenesis Imperfecta Mouse

Osteogenesis imperfecta (OI), which is most often due to a collagen type 1 gene mutation, is characterized by low bone density and bone fragility. In OI patients, gender-related differences were reported, but data in the literature are not convergent. We previously observed that sclerostin antibody...

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Bibliographic Details
Main Authors: Mickaël Cardinal, Antoine Chretien, Thomas Roels, Sébastien Lafont, Michael S. Ominsky, Jean-Pierre Devogelaer, Daniel H. Manicourt, Catherine Behets
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Genetics
Subjects:
osteogenesis imperfecta
oim/oim
sclerostin antibody
fracture
bone quality
biomechanical strength
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.705505/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.705505/full

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