The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells

The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells

Lymphocyte homeostasis, activation and differentiation crucially rely on basal autophagy. The fine-tuning of this process depends on autophagy-related (ATG) proteins and their interaction with the trafficking machinery that orchestrates the membrane rearrangements leading to autophagosome biogenesis...

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Bibliographic Details
Main Authors: Francesca Finetti, Chiara Cassioli, Valentina Cianfanelli, Fabrizia Zevolini, Anna Onnis, Monica Gesualdo, Jlenia Brunetti, Francesco Cecconi, Cosima T. Baldari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intraflagellar transport
vesicular trafficking
ATG16L1
early endosomes
autophagy
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.634003/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.634003/full

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