Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties

The synthesis of four novel platinum complexes, bearing N6-(6-amino-hexyl)adenosine or a 1,6-di(adenosin-N6-yl)-hexane respectively, as ligands of mono-functional cisplatin or monochloro(ethylendiamine)platinum(II), is reported. The chemistry exploits the high affinity of the charged platinum centre...

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Bibliographic Details
Main Authors: Stefano D'Errico, Giorgia Oliviero, Nicola Borbone, Vincenzo Piccialli, Brunella Pinto, Francesca De Falco, Maria Chiara Maiuri, Rosa Carnuccio, Valeria Costantino, Fabrizia Nici, Gennaro Piccialli
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
platinum complexes
nucleosides
cisplatin
chemotherapy
Online Access:http://www.mdpi.com/1420-3049/19/7/9339

Internet

http://www.mdpi.com/1420-3049/19/7/9339

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