Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation.

Post-transcriptional modifications of transfer RNAs (tRNAs) have long been recognized to play crucial roles in regulating the rate and fidelity of translation. However, the extent to which they determine global protein production remains poorly understood. Here we use quantitative proteomics to show...

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Bibliographic Details
Main Authors: Wenjun Deng, I Ramesh Babu, Dan Su, Shanye Yin, Thomas J Begley, Peter C Dedon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4689569?pdf=render