The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models

The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models

Transmural differences in ventricular myocardium are maintained by electromechanical coupling and mechano-calcium/mechano-electric feedback. In the present study, we experimentally investigated the influence of preload on the force characteristics of subendocardial (Endo) and subepicardial (Epi) sin...

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Bibliographic Details
Main Authors: Anastasia Khokhlova, Pavel Konovalov, Gentaro Iribe, Olga Solovyova, Leonid Katsnelson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
single cardiomyocytes
mechanical preload
length-dependent activation
transmural differences
electromechanical coupling
mechano-calcium-electric feedback
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00171/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00171/full

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