Nucleotide-Binding Oligomerization Domain 2 Contributes to Limiting Growth of Mycobacterium abscessus in the Lung of Mice by Regulating Cytokines and Nitric Oxide Production

Nucleotide-Binding Oligomerization Domain 2 Contributes to Limiting Growth of Mycobacterium abscessus in the Lung of Mice by Regulating Cytokines and Nitric Oxide Production

Mycobacterium abscessus is a prominent cause of pulmonary infection in immunosuppressed patients and those with cystic fibrosis. Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic receptor which senses a bacterial peptidoglycan component, muramyl dipeptide (MDP). Although nucleotide-bi...

Full description

Bibliographic Details
Main Authors: Jun-Young Lee, Moo-Seung Lee, Dong-Jae Kim, Soo-Jin Yang, Sang-Jin Lee, Eui-Jeong Noh, Sung Jae Shin, Jong-Hwan Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
nucleotide-binding oligomerization domain 2
muramyl dipeptide
Mycobacterium abscessus
macrophages
mitogen-activated protein kinases
nitric oxide
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01477/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01477/full

Similar Items