A Novel Role for the DNA Repair Enzyme 8-Oxoguanine DNA Glycosylase in Adipogenesis

A Novel Role for the DNA Repair Enzyme 8-Oxoguanine DNA Glycosylase in Adipogenesis

Cells sustain constant oxidative stress from both exogenous and endogenous sources. When unmitigated by antioxidant defenses, reactive oxygen species damage cellular macromolecules, including DNA. Oxidative lesions in both nuclear and mitochondrial DNA are repaired via the base excision repair (BER)...

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Bibliographic Details
Main Authors: Sai Santosh Babu Komakula, Bhavya Blaze, Hong Ye, Agnieszka Dobrzyn, Harini Sampath
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
adipocyte differentiation
DNA repair
base excision repair
lipid accretion
obesity
Online Access:https://www.mdpi.com/1422-0067/22/3/1152

Internet

https://www.mdpi.com/1422-0067/22/3/1152

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