Citric Acid Cycle Metabolites Predict Infarct Size in <i>Pigs</i> Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning

Citric Acid Cycle Metabolites Predict Infarct Size in <i>Pigs</i> Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning

Succinate dehydrogenase (SDH) inhibition with malonate during reperfusion reduced myocardial infarction in animals, whereas its endogenous substrate, succinate, is detected in plasma from STEMI patients. We investigated whether protection by SDH inhibition is additive to that of remote ischemic perc...

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Bibliographic Details
Main Authors: Marta Consegal, Norberto Núñez, Ignasi Barba, Begoña Benito, Marisol Ruiz-Meana, Javier Inserte, Ignacio Ferreira-González, Antonio Rodríguez-Sinovas
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
succinate dehydrogenase
malonate
remote ischemic conditioning
myocardial infarction
ischemia-reperfusion
Online Access:https://www.mdpi.com/1422-0067/22/8/4151

Internet

https://www.mdpi.com/1422-0067/22/8/4151

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