Envelope-Specific Adaptive Immunity following Transplantation of Hematopoietic Stem Cells Modified with VSV-G Lentivirus

Envelope-Specific Adaptive Immunity following Transplantation of Hematopoietic Stem Cells Modified with VSV-G Lentivirus

Current approaches for hematopoietic stem cell gene therapy typically involve lentiviral gene transfer in tandem with a conditioning regimen to aid stem cell engraftment. Although many pseudotyped envelopes have the capacity to be immunogenic due to their viral origins, thus far immune responses aga...

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Bibliographic Details
Main Authors: Blake J. Rust, Pamela S. Becker, Devikha Chandrasekaran, Sara P. Kubek, Christopher W. Peterson, Jennifer E. Adair, Hans-Peter Kiem
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adaptive immunity
VSV-G envelope
vector pseudotype
lentivirus
transplant
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302060

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http://www.sciencedirect.com/science/article/pii/S2329050120302060

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