Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis [version 1; referees: 2 approved]
Dihydrofolate reductase from Escherichia coli (ecDHFR) serves as a model system for investigating the role of protein dynamics in enzyme catalysis. We discuss calculations predicting a network of dynamic motions that is coupled to the chemical step catalyzed by this enzyme. Kinetic studies testing t...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2015-12-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/4-1464/v1 |