Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeast.

Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We...

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Bibliographic Details
Main Authors: Matthew North, Vickram J Tandon, Reuben Thomas, Alex Loguinov, Inna Gerlovina, Alan E Hubbard, Luoping Zhang, Martyn T Smith, Chris D Vulpe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166172?pdf=render