Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA.Methods: The frequencies of...

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Main Authors: Patricia Ruiz-Limon, Rafaela Ortega-Castro, Nuria Barbarroja, Carlos Perez-Sanchez, Christophe Jamin, Alejandra Maria Patiño-Trives, Maria Luque-Tevar, Alejandro Ibáñez-Costa, Laura Perez-Sanchez, Iván Arias de la Rosa, MaCarmen Abalos-Aguilera, Yolanda Jimenez-Gomez, Jerusalem Calvo-Gutierrez, Pilar Font, Alejandro Escudero-Contreras, Marta E. Alarcon-Riquelme, Eduardo Collantes-Estevez, Chary López-Pedrera, the PRECISESADS Clinical Consortium and Flow Cytometry Study Group, C Marañón, L Le Lann, N Varela, B Muchmore, A Dufour, Alvarez, C Carlo Montserrat Chizzolini, E, NB De Langhe, CL-P, V Gerl, A De Groof, J Ducreux, E Trombetta, T Li, D Alvarez-Errico, S Rao, JO Pers, L Beretta, R AguilarQuesada, MA Aguirre-Zamorano, JL Callejas Rubio, MC Castro-Villegas, R Cervera, C Chizzolini, E Collantes, D Cornec, E De Langhe, V Devauchelle-Pensec, AE-C, G Espinosa, MC Fernández Roldán, T Gomes Anjos, F Hiepe, I Jiménez Moleón, S Jousse-Joulin, B Lauwerys, A López-Berrio, R Lories, J Marovac, PL Meroni, B Miranda, H Navarro-Linares, R Ortega-Castro, N Ortego, E Ramón Garrido, E Raya, R Ríos Fernández, I Rodríguez-Pintó, A Saraux
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
cardiovascular disease
monocyte subsets
microRNAs
gene profile
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01111/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01111/full

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