Structure-guided microbial targeting of antistaphylococcal prodrugs

Structure-guided microbial targeting of antistaphylococcal prodrugs

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydroly...

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Bibliographic Details
Main Authors: Justin J Miller, Ishaan T Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A Mueller, Ahmed M Moustafa, Rachel L Edwards, Cynthia S Dowd, Paul J Planet, Florian L Muller, Joseph M Jez, Audrey R Odom John
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
Staphylococcus aureus
antibacterial
prodrug
drug discovery
esterase
Online Access:https://elifesciences.org/articles/66657

Internet

https://elifesciences.org/articles/66657

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