Simultaneous determination of itraconazole and its CYP3A4-mediated metabolites including N-desalkyl itraconazole in human plasma using liquid chromatography-tandem mass spectrometry and its clinical application

Simultaneous determination of itraconazole and its CYP3A4-mediated metabolites including N-desalkyl itraconazole in human plasma using liquid chromatography-tandem mass spectrometry and its clinical application

Abstract Background Itraconazole (ITZ), a triazole antifungal agent, is metabolized to hydroxy-ITZ (OH-ITZ), keto-ITZ (KT-ITZ), and N-desalkyl ITZ (ND-ITZ) by cytochrome P450 3A4. The pharmacokinetics of ND-ITZ remain largely unknown due to the lack of an accurate and reliable determination method....

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Bibliographic Details
Main Authors: Yumi Imoto, Yasuaki Mino, Takafumi Naito, Takaaki Ono, Junichi Kawakami
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Itraconazole
Metabolites
LC-MS/MS
Human plasma
Pharmacokinetics
Online Access:http://link.springer.com/article/10.1186/s40780-020-00167-7

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http://link.springer.com/article/10.1186/s40780-020-00167-7

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