The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts

The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts

IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with...

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Bibliographic Details
Main Authors: Andreas Recke, Sarah Konitzer, Susanne Lemcke, Miriam Freitag, Nele Maxi Sommer, Mohammad Abdelhady, Mahsa M. Amoli, Sandrine Benoit, Farha El-Chennawy, Mohammad Eldarouti, Rüdiger Eming, Regine Gläser, Claudia Günther, Eva Hadaschik, Bernhard Homey, Wolfgang Lieb, Wiebke K. Peitsch, Claudia Pföhler, Reza M. Robati, Marjan Saeedi, Miklós Sárdy, Michael Sticherling, Soner Uzun, Margitta Worm, Detlef Zillikens, Saleh Ibrahim, Gestur Vidarsson, Enno Schmidt, the German AIBD Genetic Study Group, Alexander Kreuter, Christos C. Zouboulis, Georg Däschlein, Kerstin Steinbrink, Manfred Kunz, Nicolas Hunzelmann, Steven Goetze
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
immunology
dermatology
autoantibodies
allotype
pemphigus
pemphigoid
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01788/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01788/full

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