Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences

Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 an...

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Bibliographic Details
Main Authors: Maria Grazia Romanelli, Carlo Bidoia, Gianfranco Di Gennaro, Francesca Avesani, Marco Turci, Umberto Bertazzoni
Format: Article
Language:English
Published: MDPI AG 2011-05-01
Series:Viruses
Subjects:
HTLV
Tax-1
Tax-2
signal transduction
cellular localization
post-translational modifications
NF-kB
PDZ binding motif
Online Access:http://www.mdpi.com/1999-4915/3/5/541/

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http://www.mdpi.com/1999-4915/3/5/541/

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