DNA-guided photoactivatable probe-based chemical proteomics reveals the reader protein of mRNA methylation

Summary: Chemical modification on mRNA can recruit specific binding proteins (readers/partners) to determine post-transcriptional gene regulation. However, the identification of the reader is extremely limited owing to the rather weak and highly dynamic non-covalent interactions between mRNA modific...

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Bibliographic Details
Main Authors: Yepei Huang, Xue Bai, Zhenchang Guo, Hanyang Dong, Yun Fu, Hui Zhang, Guijin Zhai, Shanshan Tian, Ye Wang, Kai Zhang
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221010142