A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells

A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells

Abstract Background Breast cancer is the most common malignancy in women worldwide. Although the endocrine therapy that targets estrogen receptor α (ERα) signaling has been well established as an effective adjuvant treatment for patients with ERα-positive breast cancers, long-term exposure may event...

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Bibliographic Details
Main Authors: Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt, Olga Kovalchuk
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
Antiestrogen resistance
Breast cancer
DNA methylation
Fulvestrant
GNB4
Tamoxifen
Online Access:http://link.springer.com/article/10.1186/s12885-018-4711-0

Internet

http://link.springer.com/article/10.1186/s12885-018-4711-0

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