Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.

Here, we investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis, collagen II-induced arthritis (CIA). Targeting the expression of the collagen type II (CII) to antigen presenting cells (APCs) induced antigen-specific tolerance, wher...

Full description

Bibliographic Details
Main Authors: Sara Tengvall, Tove Eneljung, Pernilla Jirholt, Olof Turesson, Kajsa Wing, Rikard Holmdahl, Jan Kihlberg, Anna Stern, Inga-Lill Mårtensson, Louise Henningsson, Kenth Gustafsson, Inger Gjertsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4861286?pdf=render

Internet

http://europepmc.org/articles/PMC4861286?pdf=render

Similar Items