Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats

Background: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles involving GLUT1, GLUT4, Akt, and AMPK, as well as GLUT4 t...

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Bibliographic Details
Main Authors: Patricia Siques, Julio Brito, Karen Flores, Stefany Ordenes, Karem Arriaza, Eduardo Pena, Fabiola León-Velarde, Ángel L. López de Pablo, M. C. Gonzalez, Silvia Arribas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
altitude
chronic intermittent hypoxia
insulin sensitivity
GLUT4
AMPK and Akt
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00799/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00799/full

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