Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates

Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates

Hybrid molecules combining photoactivated aryl acetylenes and a dicationic lysine moiety cause the most efficient double-strand (ds) DNA cleavage known to date for a small molecule. In order to test the connection between the alkylating ability and the DNA-damaging properties of these compounds, we...

Full description

Bibliographic Details
Main Authors: Wang-Yong Yang, Samantha A. Marrone, Nalisha Minors, Diego A. R. Zorio, Igor V. Alabugin
Format: Article
Language:English
Published: Beilstein-Institut 2011-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cancer cell proliferation assay
DNA alkylation
lysine conjugate
photocycloaddition
photo-DNA cleavage
plasmid relaxation assay
triplet excitation
Online Access:https://doi.org/10.3762/bjoc.7.93

Internet

https://doi.org/10.3762/bjoc.7.93

Similar Items