Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates
Hybrid molecules combining photoactivated aryl acetylenes and a dicationic lysine moiety cause the most efficient double-strand (ds) DNA cleavage known to date for a small molecule. In order to test the connection between the alkylating ability and the DNA-damaging properties of these compounds, we...
Main Authors: | Wang-Yong Yang, Samantha A. Marrone, Nalisha Minors, Diego A. R. Zorio, Igor V. Alabugin |
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Format: | Article |
Language: | English |
Published: |
Beilstein-Institut
2011-06-01
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Series: | Beilstein Journal of Organic Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.3762/bjoc.7.93 |
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